By Masumi Inaba M.D., Yoshikata Inaba M.D. (auth.)
The authors have perfected a thick-tissue training approach for watching hair at a variety of phases of progress, and their findings problem the at present held three-stage universal hair cycle. they've got recommend a brand new speculation, the four-stage crucial hair cycle, that comes with their discovery that stem cells can be found within the isthmal component to the sebaceous gland. the basic hair cycle is then used to study the standards contributing to the method of androgenetic alopecia, or untimely balding, because it is often referred to as. this is often by means of a proof of a few basic measures for the prevention of androgenetic alopecia and an outline of the remedies to be had.
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Additional info for Androgenetic Alopecia: Modern Concepts of Pathogenesis and Treatment
9b). The development of the hair canal has been described in the mouse (Hardy 1949; Davidson and Hardy 1952), in humans (Pinkus 1958), in sheep (Hardy and Lyne 1956a), and in a marsupial (Lyne 1970). In the sheep, the hair canal is formed by the 32 3. Generation and Growth of Human Hair keratinization of cells in the epidermis and by disintegration of sebaceous gland cells that have migrated to the neck of the follide. Eventually a continuous canal runs from the follide neck to the upper part of the epidermis.
C hair peg slage hair germ stage ! --- . ': ~: F . Q " r r Fig. 10. Two hypotheses for the development of human hair follicle (from Inaba 1985) a b Fig. 11. a The bulbous peg stage. The hair follicle in IVa (in Fig. 1b) is longer than that in stage III. The lower part of the follicle has formed a hair bulb and is wrapped around the mesenchymal tissue. x 600 b The bending phenomenon (arrow) is clearly seen. X600 c The new young hair has not emerged on the skin surface. Its apex is protected by cyst formation (hair canal).
X600 d The new hair has not yet emerged on the skin surface. It ascends with the development of the matrix. 1 Stages of Hair Growth 29 - ) Melanocyte protects the new young hair apex from damage. When the tip of the new hair, protected by the inner root sheath, reaches the upper isthmal portion, the new young hair starts to grow through the hair canal to be pushed out of the dermis. Apocrine gland In contrast with the conventional theory that the hair canal is formed in the dermis and epider- .
Androgenetic Alopecia: Modern Concepts of Pathogenesis and Treatment by Masumi Inaba M.D., Yoshikata Inaba M.D. (auth.)