By Jeff Goldberg
Announcing their findings to the medical international thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists around the globe have been rapidly studying the human mind and its endorphins. In many years’ time, they might use the team’s preliminary study to hyperlink endorphins to drug dependancy, runner’s excessive, urge for food keep watch over, sexual reaction, and psychological health problems corresponding to melancholy and schizophrenia.
In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives ahead of, in the course of, and after their historical and medical step forward. He additionally takes a glance on the larger photo, revealing the brutal pageant among drug businesses to discover the way to profit from this enormous discovery.
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Additional info for Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine
Kosterlitz found that morphine and similar drugs would quell this spasm to a degree directly corresponding to their painkilling potency in humans. As a result, Kosterlitz’s guinea pig ileum had become widely used in the research community as a tool to predict how effective new narcotic drugs would be in clinical practice. It was not, however, the sort of work that made one famous. In fact, to all but a small circle of serious drug researchers in Great Britain and America, his twenty-year romance with the guinea pig ileum was something of a joke, a throwback to turn-of-the-century methods.
Mayer went back and took a closer look at Wolfle’s stymied efforts to train PAG-stimulated rats to high jump. “The animals had a tendency to violently turn in one direction when the current was applied,” Mayer recounts. “They were turning and banging their heads against the wall of the cage, bloodying up their faces, but they didn’t seem to mind. That was strange, so I started poking and prodding and . . ” During the spring and early summer of 1970, Mayer and Huda Akil, who had arrived in Liebeskind’s lab eight months earlier, set out to detail this stimulation-produced analgesia.
Beckett had reasoned that how well opiates worked varied with their ability to “fit” into his conjectural opiate receptors. One variation, etorphine, which was ten thousand times stronger than morphine and useful only as a wild-game tranquilizer, seemed to fit the receptor lock more precisely than any other opiate. ” While nalorphine was also a good fit, it would block, without activating, those same target sites, thereby reversing some of the physical and emotional effects of opiates in addicts.
Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine by Jeff Goldberg