Download PDF by N M Hooper; Humana Press: Alzheimer's disease : methods and protocols

By N M Hooper; Humana Press

ISBN-10: 0585395071

ISBN-13: 9780585395074

ISBN-10: 0896037371

ISBN-13: 9780896037373

ISBN-10: 1592591957

ISBN-13: 9781592591954

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Et al. (1998) Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling. Neuroreport 9, 1481–1486. 74. , et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease. Nat. Med. 2, 864–870. 75. Borchelt, D. , Thinakaran, M. , Eckman, C. , Lee, M. , et al. (1996) Familial Alzheimer’s disease linked presenilin-1 variants elevate A beta 1–42/1–40 ratio in vitro and in vivo.

Et al. (1998) Alpha-2-macroglobulin is genetically asociated with Alzheimer’s disease. Nature Genet. 19, 357–360. Primary Drug Therapies for AD 45 3 Advances in Methodology and Current Prospects for Primary Drug Therapies for Alzheimer’s Disease David S. Knopman 1. Introduction There has been gratifying progress in the development of drugs for Alzheimer’s disease (AD). Even though the current generation of medications, the cholinesterase inhibitors (CEIs), has produced only modest benefits, our concept of an “effective” therapy has matured considerably over this time.

It is also apparent that genetic factors lead to quantitatively worse brain disease but not to a qualitatively different pattern of brain involvement. Despite some of the pitfalls of the amyloid cascade hypothesis, the deposition of Αβ seems to be the neuropathological factor most strongly influenced by genetic factors, and any hypothesis of the pathogenesis of AD must address the mechanisms of proteinacious deposition of Αβ and tau. Thus, AD is probably similar to other complex trait diseases in that there may be a common pathophysiological process to which various genetic and environmental influences might 36 Brindle and St.

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Alzheimer's disease : methods and protocols by N M Hooper; Humana Press

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