New PDF release: Advances in Network Electrophysiology: Using Multi-Electrode

By Jerome Pine (auth.), Makoto Taketani, Michel Baudry (eds.)

ISBN-10: 0387258574

ISBN-13: 9780387258577

ISBN-10: 0387258582

ISBN-13: 9780387258584

This publication booklet is an try and overview the hot development in either electronics and computational instruments built to research the sensible operations of enormous ensembles of neurons and to supply the readers with a feeling of the purposes made attainable through those technological instruments. whereas substantial development has been revamped the final many years in our figuring out of electrophysiological approaches on the unmarried channel, single

synapse, and unmarried neuron degrees, our figuring out of electrophysiological

processes on the neuronal community point continues to be in its infancy.

This booklet includes:

  • Technological overviews of multi-electrode arrays (MEAs) and similar electronics and software,
  • Applications of MEAs to review ensemble job of dissociated telephone cultures together with cardiac myocytes,
  • Applications of the know-how for drug discovery utilizing acute and cultured slices.

Examples of experiences directed at figuring out the origins and features of assorted rhythmic actions in neuronal ensembles.

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Additional resources for Advances in Network Electrophysiology: Using Multi-Electrode Arrays

Sample text

And Fromherz, P. (2002). Transistor array with an organotypic brain slice: field potential records and synaptic currents. Eur. J. Neurosci. 15: 995–1005. B. and Pine, J. (1991). Voltage-sensitive dye recording of action potentials and synaptic potentials from sympathetic microcultures. Biophys. J. 60: 697–711. Claverol-Tinture, E. and Pine, J. (2002). Extracellular potentials in low-density dissociated neuronal cultures. J. Neurosci. Meth. 117: 13–21. E. (1986). Multielectrode analysis of coordinated, multisite, rhythmic bursting in cultured CNS monolayer networks.

In addition to the 32 recording electrodes, 2 indifferent and 2 large ground electrodes are incorporated in this design. The polyimide is perforated to allow better attachment of the tissue to the array as well as axonal growth. 5 High-Density MEA For various reasons, spatial resolution is important when conduction velocity or synaptic delays are to be measured precisely over a long distance. Given 60 electrodes there is either a very good spatial resolution (small interelectrode distance) and a small recording area, or vice versa.

Multielectrode recording from the vertebrate retina. Invest. Ophthalmol. Vis. ): 68. A. (1994). Neurosci. Meth. 51: 95–106. J. (1991). Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina. Science 252: 939–943. L. C. (1988). Multisite hippocampal slice recording and stimulation using a 32 element microelectrode array. J. Neurosci. Meth. 23: 149–159. , and Taketani, M. (1999). A new planar multielectrode array for extracellular recording: Application to hippocampal acute slice.

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Advances in Network Electrophysiology: Using Multi-Electrode Arrays by Jerome Pine (auth.), Makoto Taketani, Michel Baudry (eds.)

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